Th17 cells were later confirmed to be a central player in host protection against certain mucosal pathogens and an important target for therapeutic intervention in mucosal inflammatory diseases. demonstrated that the presence of segmented filamentous bacteria (SFB) in mice could massively skew the frequency of Th17 cells, a subset of CD4+ T helper cells that produce interleukin-17 (IL-17) and IL-22 in the lamina propria 1. Despite the presence of hundreds of species of bacteria in the intestinal tract, Ivanov et al. In 2009, Dan Littman's laboratory published a landmark manuscript that greatly influenced how the research community viewed commensal microbes and their impact on the host immune system. Taconic-Biomodels Microbiome Initiative.Fecal Microbiota Transplantation Service.Microbiome Solutions and Germ-Free Mice.Model Generation Solutions Publications.E xpressMODEL® Random Integration Transgenic. Mice described in Concepcion et al., Plos Genetics 2011 Mice described in Han, Vidigal, Mu, et al Nature Genetics 2015 We recommend you contact them directly to secure the mice as soon as they are made available). (Note: Jax is still processing this strain, so the link may not be functional yet. Halo-Ago2 conditional knockin mouse described in Li, Prytikin, Concepcion et al., Mol Cell, 2020 Our mice at Jacksonĭox-inducible T6B transgenic mouse described in La Rocca, King et al., eLife, 2021JAX Stock No. To request reagents not included in this list, please contact us at plasmids on AddGene Halo-enhanced Ago2 pulldown (HEAP)ĭownload the computational pipelin e or a detailed HEAP protocolrelated to Li, Prytikin, Concepcion et al. To facilitate the process, and to reduce the costs for our laboratory, we distribute all our genetically engineered mice through the Jackson laboratories, and our most popular plasmids via Addgene. We believe that science should be a free and open endeavor and we will promptly share any published reagents with the rest of the scientific community.
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